fidzu : computers

CNN reports that "A one-time snip of a key gene lowered heart-clogging cholesterol by about 50% over an entire year with no adverse effects, scientists have reported." The overwhelmingly positive results were found in four people who had taken the highest dose of the experimental treatment during a pilot study published in The New England Journal of Medicine in November 2025. That study was extremely small - only 15 patients with dangerously high cholesterol that did not respond to medication. The research was designed to test the safety of five different doses of a gene-altering infusion delivered by CRISPR-Cas9, a biological scissor which cuts a targeted genetic location to modify or turn a gene on or off. "If you'd asked me 15 years ago if we could have done something like this, I would have thought you were crazy," senior study author Dr. Steven Nissen, chief academic officer of the Sydell and Arnold Miller Family Heart, Vascular & Thoracic Institute at Cleveland Clinic in Ohio, told CNN previously. An update on the study, published Friday in NEJM, appears to answer a key question: Does the intervention last? "Is something like this truly a one and done? That was always the question," said lead study author Dr. Luke Laffin, a preventive cardiologist at Cleveland Clinic's Heart, Vascular & Thoracic Institute. "This new data is essentially saying that the decreases in LDL cholesterol and triglycerides we saw at 60 days after treatment have lasted over a year," Laffin said. "In people who took the highest dose, the reduction seems durable and safe...." If larger clinical trials show similar results, the procedure could be a game changer for young people with severe disease, preventive cardiologist Dr. Ann Marie Navar, an associate professor of cardiology at UT Southwestern Medical Center in Dallas, told CNN previously. "If you're 20 and you have really high cholesterol, it may make a lot more sense to have a one-time treatment that doesn't require you to have to take a pill every single day or shot every two weeks for the next 60 years," said Navar, who was not involved in the study. "The potential for this is just enormous." Being born with this mutation naturally "drastically lowers or even eliminates a person's risk for heart disease," the article points out. And the study's senior author adds "now that CRISPR is here, we have the ability to change other people's genes so they too can have this protection."

Read more of this story at Slashdot.

29 Aug 2026 9:00pm GMT

The Washington Post shares this tip for car buyers. Electric vehicles "are not driving the recent growth in recalls warning that vehicles could erupt into flames at any time, even when parked and turned off." A Washington Post analysis of National Highway Traffic Safety Administration (NHTSA) recall notices found that conventional gas and diesel vehicles made up the vast majority of vehicles covered by the "park outside" label since 2021. Last week, The Post wrote about an alarming surge in these so-called "park outside" recalls... A total of an estimated 3.4 million vehicles currently have outstanding recalls of this kind, according to vehicle history provider CarFax. Safety experts say the surge in "park outside" recalls appears to be caused by other changes to modern gas and electric vehicles, such as the additional technology in everything from transmissions to seat warmers.... [It's a messy mix of things that "doesn't lend itself to simple description of what's happening," says Sean Kane, president of auto safety-analysis firm Safety Research and Strategies. "But it boils down to growing electronic systems and the number of components."] They're known as "key-off fires," said Frank Borris, a former NHTSA investigator who now works as a safety consultant. "The engine is off," he said, "but the circuits are still hot and they stay hot all the time." Earlier this year, Kia needed to recall 463,000 Tellurides because of the risk that the front power-seat switch could overheat and ignite the seat. That was the second time Kia had issued a recall for that one defect. The first recall, in 2024, didn't fully address the problem. More than 66,000 Ford Expeditions and Lincoln Navigators from the 2021 model year were recalled due to circuit boards in the battery junction box that could short out. At least 16 fires were blamed on the problem, which often ignited when the vehicles were parked and turned off. NHTSA has issued 93 "park outside" recalls since 2021, according to a Post analysis. Nearly half - 44 recalls - covered vehicles exclusively with conventional internal-combustion engines, while 38 recalls were just for EVs or hybrids. So the number of campaigns were nearly equally divided between gas and electric or hybrid vehicles. But gas vehicles pull away when comparing the size of the recalls. Gas-only campaigns covered a combined 4.6 million vehicles with "park outside" recalls over the past five years, compared to only about 662,000 vehicles that were EVs or hybrids... Other countries have provided limited looks at the EV fire issue, such as an United Kingdom government review of data from Norway finding that gas and diesel vehicles had a fire incidence rate that was four times higher than EVs from 2016 to 2021. Just in 2026, U.S. authorities have announced 17 new "park outside" recalls covering 1.7 million vehicles, according to the article.

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29 Aug 2026 8:00pm GMT

The Washington Post looks "a growing number of Americans who have had their private conversations with AI chatbots made public in court," calling the chatbots "custodians of a fast-growing trove of intimate data that can be sought by law enforcement, or companies or other opponents in civil litigation." A Washington Post review of public records and local news stories found that chatbot logs were cited in 12 court cases over the past two years. It's hard to know how often chatbot material is drawn into investigations and legal proceedings more broadly, because police, and parties in civil cases, don't have to present in court all the evidence they obtain... In some cases, AI companies have reported people on their platforms to the FBI, leading to prosecutions and at least one conviction... OpenAI has said the company uses software to scan conversations for signs of dangerous behavior and flag them to human reviewers. If a reviewer determines a chat indicates "an imminent and credible risk of harm to others," they report the user to law enforcement, the company said in an April blog post. A spokesperson for OpenAI declined to disclose how many times the company had reported users to police.... Data released by OpenAI shows requests by government agencies and law enforcement for user data growing rapidly. In the second half of 2025, the company disclosed data from more than 80 accounts, an increase of more than four times as many over the same period the year before... When police ask someone to open their phone during questioning or after an arrest, they often do so, allowing officers to scroll through the apps they use, [according to Michael Price, the litigation director for the Fourth Amendment Center at the National Association of Criminal Defense Lawyers]... In general, the Fourth Amendment, which protects people against unreasonable searches and seizures of their property, provides the right to refuse a search of the contents of their phone unless police have a warrant. "The short answer is that most people consent," Price said. "They shouldn't, but they do..." OpenAI CEO Sam Altman has argued that conversations with chatbots should receive special legal protections, similar to conversations between clients and their attorneys. Special legal protections aren't recognized by courts today, the article poitns out. A financial executive who became the subject of a federal criminal investigation for fraud asked Claude about potential defense strategies, then asked a judge to disallow the conversations from the prosecution's case, according to the article. "But the judge said that protections for conversations between clients and their attorneys did not apply: Claude is not a lawyer, and the executive's attorneys did not ask him to talk to the chatbot." The article includes quotes from three ChatGPT conversations that later turned up in court proceedings: "I deleted a email a year ago from my yahoo account. Can yahoo still retrieve the email?" "How f----d am i bro. What if i smahsed the s--- oitta mutlipls cars." "My dad Said that I'm will get a settlement worth of 1million dollar." "As AI becomes a bigger part of everyday life, its use as evidence and in trials is likely to become more prevalent," the article points out - especially with the growing popularity of agents that take actions for users.

Read more of this story at Slashdot.

29 Aug 2026 7:00pm GMT

Testing 100 companies found privacy requests often led to confusion and dead ends.

29 Aug 2026 10:50am GMT

Kalshi can't evade Nevada gambling laws by calling bets "swaps," judges rule.

28 Aug 2026 10:14pm GMT

Cancellations have accelerated.

28 Aug 2026 9:33pm GMT

Virtually all laptop speakers suck. It's the one area where even really expensive laptops tend to fall on their ass, leaving users with a tinny, harsh, and hollow sound experience. While you can't exactly overcome physics - laptop speakers are necessarily small and thus just cannot ever sound as good as proper speakers - there's a lot you can do with proper tuning and software magic. If you're a desktop Linux user, you actually already possess all the plumbing needed to fix your audio; it's just not exposed to you in any way. Luckily, an application called EasyEffects allows you to actually make use of desktop Linux' advanced audio features to massively improve the sound quality of your laptop's speakers. EasyEffects' own description on its GitHub page doesn't really explain what it does or what it's capable of, so here's the description from Wikipedia instead. EasyEffects uses PipeWire to process incoming and outgoing audio streams independently and can apply various sound effects in the form of plug-ins made by different developer teams such as Calf Studio Gear, MDA.LV2 and GStreamer. All plugins have their own presets and can be applicable inside the suite rather than having to use a different mixer or executing a script from the command line. Available output effects are limiter, auto volume, compressor of dynamic range, filter, 30 bands parametric equalizer, bass enhancer, exciter, reverbation, crossfeed, delay, maximizer and spectrum analyzer. Available input effects are WebRTC, limiter, compressor, filter, equalizer, de-esser, reverbation, pitch shift and spectrum analyzer. ↫ EasEffects' Wikipedia page None of this matters, and you can forget everything from these two paragraphs. What matters is that using EasyEffects, you can tune the audio coming out of your speakers to make them sound a lot better. The few laptops on the market that do have decent audio - MacBooks, some Dell XPS laptops, and surely a few more - aren't magically defying physics. While they probably do have objectively higher-quality speakers, the main difference between those laptops and laptops with crappy-sounding speakers is that the former come with built-in tuning from the factory to make them sound much better than they would without any software trickery. If you know your way around audio, you can very much use EasyEffects and tune your laptop speakers from scratch to massively improve how they sound. However, that requires time, experience, knowledge, and expertise that most people lack, including myself. Lucky for us, though, there are countless downloadable presets out there for EasyEffects designed specifically to make laptops sound better. In an ideal world, you'd pick a preset created specifically for your laptop make and model, but odds are you won't find one, so for most laptops you'll have to settle for a generic preset that tries to do its best. I've long settled on the Advanced Auto Gain.json preset from JackHack96, which greatly improves the audio performance on any laptops I've tried it on, but of course, there's countless other presets for you to try to see if there's anything that suits your particular laptop and ears better. Getting all of this up and running is really easy. EasyEffects is most likely packaged by your Linux distribution, and the latest version is always available as a Flatpak from Flathub. Download the preset(s) you want to try, copy them either to ~/.config/easyeffects (if you use your distribution's package) or to ~/.var/app/com.github.wwmm.easyeffects/data/easyeffects/output/ (if you use the Flatpak version). They'll show up right away in the Presets tab in EasyEffects, ready to be turned on and off whenever you want, making it very easy to compare and contrast to find the one you like best. EasyEffects can live in your system tray giving you easy access to your presets without having to open the main window, and it can be set to start automatically at boot. EasyEffects can also be turned on and off on the fly. There's obvious downsides to all of this, too, of course. First, since you're most likely going to be using a generic preset not specifically crafted for your laptop, there's no guarantee the results will be positive for you. Second, not every preset is ideal for every type of audio. Most of my audio consists of YouTube videos with mostly speech; if you listen mostly to music, different presets may yield better results. Third, audio quality is deeply subjective, and what sounds good to my ears may sound like total garbage to yours. Fourth, EasyEffects does take up a tiny fraction of CPU power (I'm talking 0.1-0.2% according to KDE's System Monitor), but I have never seen it have any noticeable performance impact on anything. Even the generic preset I use makes such a massive difference for me on every laptop I've ever tried it on, that I've become convinced EasyEffects and a few of the generic presets should be installed by default by any desktop-oriented Linux distribution. On top of that, Linux laptops OEMs like System76, Nova Custom, Star Labs, and so on, should really take the time to create proper presets for their laptops to improve their sound quality out of the box. I feel like if you're already designing and selling laptops, you probably also have the skills and means to create a decent preset. In fact, I'd take it a step further and urge desktop environments like KDE and GNOME to properly integrate EasyEffects into their sound settings. They shouldn't include the entire application and its user interface, but should make it so that you can configure and manage presets right from the sound settings panels, and switch between presets from their volume applets (as well as turn it off entirely, of course). This would leave the full EasyEffects application for people who need more control, manual tuning, and more advanced features. There's absolutely no reason why speakers on Linux laptops should sound tinny, harsh, and hollow. The Linux desktop has all the technologies and features built right in to make speakers sound much better than they do without any tuning,

27 Aug 2026 8:18pm GMT

Built on a 2 nanometer technology node, the processor's design will contain 11 high-performance cores operating at more than 5.7 GHz, AI inference accelerators for in-transaction fraud detection, a dedicated on-chip data processing unit for I/O acceleration, and a large cache architecture for demanding enterprise workloads. The chip is architected to not contain separate Arm and IBM cores: each processor core can natively execute Arm and IBM Z, or Arm and LinuxONE, instructions concurrently while prioritizing the platform's established performance, security, encryption, and availability characteristics. IBM Z and LinuxONE platforms are capable of scaling to hundreds of cores and tens of terabytes of memory. ↫ IBM press release IBM is still doing some amazing chip architecture design. ServeTheHome has more details of how this works: A key choice here is that IBM implemented AArch64 in full hardware rather than through translation. This design uses a little-endian Arm implementation alongside big-endian z/Architecture, with AArch64 v9.3, SVE and SVE2 support, and 2,792 implemented AArch64 instructions. IBM also claims Arm SystemReady compliance, which matters for how much off-the-shelf Arm software this core can absorb. This is absolutely crazy technology. Arm software sees a native Arm processor. Arm runs unmodified, out-of-the-box, and onto a standard Arm platform. IBM said the 2792 AArch64 instructions are more than twice the Z instructions. IBM made a funny quip about "reduced" in RISC. ↫ Patrick Kennedy at ServeTheHome This is bonkers technology. We can only dream of this ever serving a home.

27 Aug 2026 2:30pm GMT

It's always a special day on OSNews when Haiku has a new release. While OSNews was founded in 1997, it wasn't until 2001, when Eugenia took over and relaunched the site, that we really got going. Eugenia came from BeNews, a popular BeOS news website, which shut down in the wake of Be, Inc's infamous "focus shift" away from BeOS as a general purpose desktop operating system. BeOS continues to have a special place on OSNews ever since. Today marks the release of Haiku R1/beta6, the first official Haiku release in two years. As such, this new beta covers a monumental amount of progress since beta5, progress I've reported on diligently. The highlights of this new beta include a port of Firefox (including branding) and many of its forks, much improve support for Qemu, a new memory allocated largely based on the one from OpenBSD, and improved support for various filesystems. Of course, there's a massive list of performance improvements, memory management changes, as well as a truly massive number of new application ports. It's important to note, as I usually do, that while these Haiku beta releases serve as patches of calm in rough seas, Haiku is generally stable and capable enough that using the project's nightly releases is usually a totally acceptable way of installing and running the operating system. If you're not comfortable running nightly releases, however, and haven't tried Haiku since the previous beta, you're in for a massive overall improvement. Everybody loves Haiku.

27 Aug 2026 11:31am GMT

Over the last few weeks, we have been doing research on the integration of our official distribution packages when installed on a target system. In this context we have been looking at the current uses of alpm-install-scriptlet(5) files and alpm-hooks(5) in around 120 package source repositories (alpm-source-repo(7)) to better understand the underlying functionality and use-cases these two integrations offer and target. In this article we are going to look at how these two systems work, how Arch Linux is currently using them and attempt to provide suggestions for when to use which. Learning about alpm-hooks(5) and alpm-install-scriptlet(5) files …

09 Aug 2026 12:00am GMT

This is just a short note on my blog that I have resigned from Arch Linux a package maintainer, developer and security team. I've spent around 10 years as an AUR maintainer, security team, Package Maintainer and then Developer. I implemented support for debug packages, did the initial POC work that would become the git migration and even somehow managed to pull of an online conference during The Plague with the help of others.

01 Aug 2026 12:00am GMT

Good morning from JetBrains Berlin office!

01 Jun 2026 12:00am GMT