fidzu : computers

A vibrating mattress combined with two pills that release nitric oxide enhanced the brain's ability to clear an Alzheimer's-related protein. According to New Scientist, the experiment "caused the brain's blood vessels to swell and constrict more strongly, which enhanced the glymphatic system's clearance of [the protein]." From the report: [Kesa Kiviniemi at the University of Oulu in Finland] and his colleagues recruited 29 adults who hadn't been diagnosed with Alzheimer's disease or any other cognitive issues. The participants took a pill that dissolves when under the tongue, releasing nitric oxide. They then lay on a mattress that caused their bodies to gently vibrate for 40 minutes, taking another pill halfway through. Blood samples revealed that their levels of a type of protein called beta-amyloid 42 increased by 35 per cent, on average, after the intervention. This protein, which usually helps neurons signal and connect to each other, misfolds and form clumps in Alzheimer's disease. "The treatment seemed to enhance the glymphatic system's ability to clear beta-amyloid from the brain to the blood," says Kiviniemi. "A 35 per cent increase in circulating beta-amyloid 42 is a substantial and very interesting acute effect," says Tuomas Lilius at the University of Helsinki, who wasn't involved in the work. "It is certainly possible it could become biologically, and eventually clinically, relevant." Side effects were mild and minimal, with six of the participants experiencing issues such as nausea and headache. However, this could partly be due to the expectation of an effect from the nitric oxide pills. The researchers hope to overcome this in future work by including placebo pills. Brain scans suggest the treatment enhanced the flow of fluid along glymphatic channels, probably by widening the brain's blood vessels and making them pump more strongly, says Kiviniemi. But other mechanisms could also be at play, says Brown. For instance, this intervention may slow the breakdown of beta-amyloid 42 by the liver, leading to higher amounts in the bloodstream, he says. Future studies could get around this by injecting markers into cerebrospinal fluid, which moves through the glymphatic system, to more directly measure its flow, says Brown. Additional experiments by Kiviniemi and his colleagues tested either only the mattress vibrations or only the nitric oxide pills on the same participants, at least a week before or after they underwent the combined approach. Based on brain scans, these solo interventions seemed to have less than half the effect on the glymphatic system than when they were combined. The findings have been published in the journal Nature Communications.

Read more of this story at Slashdot.

07 Nov 2026 7:00am GMT

An anonymous reader quotes a report from TorrentFreak: On Tuesday, Mexico's Senate approved (PDF) a reform of the Federal Copyright Law that ties ISP liability to having a policy to terminate repeat infringers. [This policy has to be published permanently on their website and in their terms of service, and it must include a basic way to notify users. In other words, what can be terminated is the Internet connection itself, not just an account. According to Mexican business outlet EL CEO, this means that access providers such as Telmex and Izzi will need such a policy.] The Senate approved the amendments with roughly two-thirds of the vote, as the opposition voted against. The Chamber of Deputies already approved the same text in October, so the decree now goes to President Claudia Sheinbaum. Her government proposed the changes in May to bring the law in line with the USMCA trade agreement between Mexico, the United States and Canada. [...] Providers that don't comply risk facing liability. Under the new rules, any ISP that fails to meet its safe harbor conditions becomes liable for its users' infringements if it knowingly contributes to, induces, or causes the infringement. The same goes for an ISP that can control the infringing user and profits directly from the infringement. In both cases, the Mexican Institute of Industrial Property (IMPI) can fine the provider up to roughly 4.7 million pesos (~$250,000), depending on the infringement. The law doesn't explicitly define the term repeat infringer, nor does it say how many piracy accusations it takes before a subscriber can be cut off. According to Aurora Lopez-Portillo, director of legal services at IP firm ClarkeModet, each provider has to decide its own threshold. She told EL CEO that ISPs should also check whether the accusations actually hold up, while giving users a chance to respond, even though the law doesn't require that. During Tuesday's Senate debate, some lawmakers in the opposition raised similar concerns. Senator Gabriel Elizondo warned that families can share a single connection, so the pirating activities of one person could leave an entire household offline. Previously, opposition lawmakers proposed requiring a court order before Internet service could be suspended, but that proposal was not adopted. [...] There, failing to meet the safe harbor conditions, including the repeat infringer policy, is the first requirement for liability. If an ISP also contributes to infringement with knowledge of it, or can control the infringer and directly profits from it, it can be held responsible. The new repeat infringer rules will take effect 180 days after their publication in Mexico's official gazette, which hasn't happened yet as far as we can see. How Mexican ISPs will define a repeat infringer, and how many accusations it takes, has yet to be seen.

Read more of this story at Slashdot.

07 Nov 2026 3:30am GMT

The European Commission has preliminarily found that TikTok violates the Digital Services Act because its For You recommendation algorithm can create a "rabbit hole effect," repeatedly exposing users to potentially harmful content involving topics such as sadness, isolation and body image. TikTok must change the feed's design or potentially face fines of up to 6% of its global annual revenue. The Verge reports: The findings come months after the EU Commission declared that TikTok's design is too "addictive." While TikTok has implemented controls to mitigate the algorithm's "rabbit hole effect," the Commission says its preliminary findings suggest that they're not effective. TikTok must now change the design of its For You feed, or else face fines of up to 6 percent of its global annual turnover. The platform is also facing pressure in the US, with lawmakers and a wave of lawsuits raising concerns about child safety. "Every time a user scrolls or likes a video on TikTok, the algorithm serves more of the same leading users down rabbit holes they cannot easily escape from," Henna Virkkunen, the EU Commission's executive vice president of tech sovereignty, security, and democracy, says in the press release. "Today's preliminary findings show again that TikTok needs to step up its efforts to protect users' well-being, including those of minors."

Read more of this story at Slashdot.

07 Nov 2026 12:00am GMT

It's the exact path, not the apparent severity that matters most, doctors say.

06 Nov 2026 11:09pm GMT

Iran threatened to attack subsea cables if US escalates military strikes again.

06 Nov 2026 10:41pm GMT

It's mostly bad news from EA lately, but preservation efforts are nice to see.

06 Nov 2026 10:08pm GMT

Ubuntu has been at the forefront of replacing the traditional versions of basic tools like sudo with replacements written in Rust, but aside from worries about replacing battle-tested code with brand new, relatively untested code, there's new things to worry about it. As it turns out, sudo-rs, the Rust replacement for sudo, is intentionally incompatible with the classic version in dangerous ways, as Chris Siebenmann discovered to his dismay. Basically, the classic sudo supports the use of wildcards defined using square brackets, so that if you allow a user to run, say, /usr/sbin/exim -bp, without a password, they can run exim -bpa, exim -bpc, exim -bpr, or exim -bpu without having to supply a password. This allows for very specific, fine-grained access control, which is quite a nice capability to have if you're managing many systems and users. Sadly, sudo-rs intentionally does not support this, opting to only allow you to use the generic * wildcard. Worse yet, it doesn't really make this clear, either. ↫ Chris Siebenmann I do not really have words for this. The Rust sudo has apparently opted to keep the single most dangerous wildcard while disallowing all of the wildcards that allow one to be narrow and specific about what you're allowing, and it buries this at the end of a section that devotes a bunch of words to describing functionality it doesn't have and doesn't support, with absolutely nothing else in that section to say this (either up front or in the descriptions of how all the wildcards would work if sudo-rs supported them, which it doesn't). If you're going to replace such vital, core tools like sudo that god knows how many people rely on every single day, you better be damn sure you're feature-complete and can act as a drop-in replacement. If someone switches from sudo to doas, nobody expects the experience to be identical. However, if you're consistently being told that sudo-rs is a drop-in replacement and you shouldn't expect any disruptions, you better be able to make true on that promise. Ubuntu isn't some also-ran small hobby distribution, and its developers should act like it. What a clown show.

05 Nov 2026 4:24pm GMT

The second desktop environment release I've got for you today is LXQt 2.5.0. This new version excises its last LXDE dependency, and QTerminal and QTermWidget received considerable improvements, like new background image modes, a visual bell, support for OSC-8 hyperlinks, and more. There's a ton of smaller changes and improvements as well, but do note that due to a bug, 2.5.0 broke LXQt's Monitor Settings on X11. The project intends to fix this as quickly as possible and push a point release to address this issue.

05 Nov 2026 4:03pm GMT

It's desktop environment Thursday, as I've got two new releases for you today. First, Cinnamon, the desktop environment primarily associated with Linux Mint, has hit version 6.8. This version will officially ship with Linux Mint 27, scheduled for around Christmas of this year. Highlights of Cinnamon 6.8 include hibernation support via a Suspend action in the main menu, modern one-to-one trackpad gestures for both Wayland and Xorg sessions, support for the oo7 Secret Service provider, support for multiple instances in the Sound applet, and a more unified Network applet that merges the WireGuard and VPN sections. ↫ Marcus Nestor at 9To5Linux While Cinnamon is first and foremost a Linux Mint project, it's available on countless other distributions as well, including dedicated variants for popular distributions like Fedora and Ubuntu. Its Wayland support is finally materialising too, which is long overdue.

05 Nov 2026 3:57pm GMT

This is a story of how we got from something like this: Failed to deserialize BUILDINFO file: Parser failed with the following error: unknown ^ invalid makepkg build environment option expected `buildflags`, `ccache`, `check`, `color`, `distcc`, `sign`, `makeflags` To this: When the ALPM project started, the goal was fairly simple: Better tooling to interact with the low-level plumbing of Arch Linux Package Management (ALPM). This meant binaries to read/write individual file types, better error messages, extensive specifications and of course exports to common dataformats like JSON. The thing is, although some of us already had experience with low-level dataframe parsing, …

08 Oct 2026 12:00am GMT

Over the last few weeks, we have been doing research on the integration of our official distribution packages when installed on a target system. In this context we have been looking at the current uses of alpm-install-scriptlet(5) files and alpm-hooks(5) in around 120 package source repositories (alpm-source-repo(7)) to better understand the underlying functionality and use-cases these two integrations offer and target. In this article we are going to look at how these two systems work, how Arch Linux is currently using them and attempt to provide suggestions for when to use which. Learning about alpm-hooks(5) and alpm-install-scriptlet(5) files …

09 Aug 2026 12:00am GMT

Good morning from JetBrains Berlin office!

01 Jun 2026 12:00am GMT