computers

25 Apr 2026

Slashdot

FDA Gives Green Light To the First Gene Therapy For Deafness

An anonymous reader quotes a report from NPR: The Food and Drug Administration approved the first gene therapy to restore hearing for people who were born deaf. The decision, while only immediately affecting people born with a very rare form of genetic deafness, is being hailed as a milestone in the quest to treat hearing loss. "It's the first time in history there's a new drug for hearing loss," says Zheng-Yi Chen, an associate scientist at Mass Eye and Ear in Boston who was not involved in the development of the therapy approved by the FDA Thursday. But his research team reported very promising results with a similar approach Wednesday. "I think it's an historical event, a landmark, a great development for the whole field," he says of the approval. [...] The FDA's decision was based on the results from the treatment of 20 patients born with a defective version of a gene known as OTOF, which is necessary to transmit sound from the ears to the brain. Doctors infused billions of adeno-associated viruses into the patients' ears by making a small incision behind the ear to open a small hole in the skull. The viruses carried a healthy version of the OTOF gene that had been split in half to fit inside the virus. The gene provides instructions to make the otoferlin protein, which is necessary for hair cells in the inner ear to transmit sound to the brain. Most of the patients began to hear for the first time within weeks, with the quality of their hearing improving over the following months, according to [Regeneron Pharmaceuticals, which developed the gene therapy and plans to offer it for free in the U.S. It should be available within weeks.]. The amount of hearing patients gained varied, but 80% achieved at least some significant hearing restoration and 42% ended up with normal hearing, which included the ability to hear whispers, Regeneron says. The hearing ability has lasted at least two years so far. The treatment can only help patients with the very rare form of deafness that Smith was born with, which only affects about 50 children each year in the U.S. But similar gene therapies are showing promise for other forms of genetic deafness. And researchers hope someday gene therapy may help with common types of hearing loss, like from aging and loud noise.

Maine Governor Vetoes Data Center Moratorium Bill

Maine Gov. Janet Mills vetoed a bill that would have imposed the nation's first statewide moratorium on new data centers, saying she supported the idea in principle but would not block a major redevelopment project tied to jobs and local investment. Instead, she said she will create a council to study data centers' effects while also signing a separate measure to deny them certain state tax incentives. Politico reports: "After prior redevelopment efforts failed, the Town of Jay worked for two years on a $550 million data center redevelopment project to finally bring jobs and investment back to the mill site," Mills wrote, adding that she would issue an executive order establishing a council to examine the impact of data centers in Maine. The legislation would have made Maine the first state to block the construction of new data centers, as both political parties grapple with how voters view them ahead of the midterm elections. In a statement accompanying the letter, the governor said she had signed a separate bill that would prohibit data center projects from receiving Maine's business development tax incentive programs

Ars Technica

This is who's developing Golden Dome's orbital interceptors—if they're ever built

"If boost-phase intercept from space is not affordable and scalable, we will not produce it."

25 Apr 2026 2:52am GMT

24 Apr 2026

OSnews

If 64bit Windows 11 contains a copy of 32bit explorer.exe, could you run it as its shell?

Raymond Chen published a blog post about how a crappy uninstaller on Windows caused a mysterious spike in the number of Explorer (Windows' graphical shell) crashes. It turns out the buggy uninstaller caused repeated crashes in the 32bit version of Explorer on 64bit systems, and - hold on a minute. The how many bits on the what now? The 32-bit version of Explorer exists for backward compatibility with 32-bit programs. This is not the copy of Explorer that is handling your taskbar or desktop or File Explorer windows. So if the 32-bit Explorer is running on a 64-bit system, it's because some other program is using it to do some dirty work. ↫ Raymond Chen at The Old New Thing So I had no idea that 64bit Windows included a copy of the 32bit Explorer for backwards compatibility. It obviously makes sense, but I just never stopped to think about it. This made me wonder though if you could go nuts and do something really dumb: could you somehow trick 64bit Windows into running this 32bit copy of Explorer as its shell? You'd be running 32bit Explorer on 64bit Windows using the 32bit WoW64 binaries where you just pulled the 32bit Explorer binary from, which seems like a really nonsensical thing to do. Since there's no longer any 32bit builds of Windows 11, you also can't just copy over the 32bit Explorer from a 32bit Windows 11 build and achieve the same goal that way, so you'd really have to go digging around in WoW64 to get 32bit versions. I guess the answer to this question depends on just how complete this copy of 32bit Explorer really is, and if Windows has any defenses or triggers in place to prevent someone from doing something this uselessly stupid. Of course, there's no practical reason to do any of this and it makes very little sense, but it might be a fun hacking project. Most likely the Windows experts among you are wondering what kind of utterly deranged new designer drug I'm on, but I was always told that sometimes, the dumbest questions can lead to the most interesting answers, so here we are.

24 Apr 2026 11:07pm GMT

Slashdot

BMW Is One Step Closer To Selling You a Color-Changing Car

BMW's latest concept car moves the color-changing tech it debuted back at CES 2022 closer to reality by embedding an E Ink panel directly into the hood. The Verge reports: BMW's previous concepts wrapped the entire vehicle in a patchwork of E Ink panels that were all custom-sized and shaped to match its contours. It was an approach that wasn't practical for mass production, and one that wasn't very durable. The new BMW iX3 Flow Edition is potentially the most exciting of all of BMW's concepts as it embeds the E Ink Prism technology directly into the structure of the vehicle's hood panel, instead of just slapping it on top. The new approach has "undergone BMW's stringent quality testing" so that it meets the "requirements of automotive engineering and everyday use," according to a release from E Ink. The BMW iX3 Flow Edition's color-changing capabilities are limited to its hood with eight different animations (which appear restricted to a grayscale palette) that can be changed by the driver at the push of a button. It's not exactly the color-changing car that BMW has been teasing for years and you still can't buy one, but by focusing on making this technology more practical and functional these vehicles are one step closer to moving past the concept phase.

OSnews

8087 emulation on 8086 systems

Not too long ago I had a need and an opportunity to re-acquaint myself with the mechanism used for software emulation of the 8087 FPU on 8086/8088 machines. ↫ Michal Necasek Look, when a Michal Necasek article starts out like this, you know you're in for a learnin' ol' time. The 8087 was a floating-point coprocessor for the 8086 and 8088 processors, since back in those early days, processors did not include an integrated floating-point unit. It wouldn't be until the release of the 486DX, in 1989, that Intel would integrate an FPU inside the processor itself, negating the need for a separate chip and socket. Interestingly enough, Intel also released a cut-down version of the 486 with the FPU removed, the 486SX, for which an optional external FPU did exist.

24 Apr 2026 10:42pm GMT

Ars Technica

Google will invest as much as $40 billion in Anthropic

This follows a similar, but smaller, investment by Amazon just days ago.

24 Apr 2026 10:05pm GMT

Europe—not US—first to authorize Moderna's combo mRNA flu-COVID vaccine

Amid RFK Jr.'s anti-vaccine agenda, Moderna withdrew its FDA application last year.

24 Apr 2026 9:11pm GMT

OSnews

How hard is it to open a file?

Sebastian Wick has a great explanation of why opening files - programmatically - is a lot more complex and fraught with dangers than you might think it is. This issue was relevant for Wick as he is one of the lead developers of Flatpak, for which a number of security issues have recently been discovered, and it just so happens that many of these issues dealt with this very topic. The biggest security issue found was a complete sandbox escape, originating from the fact that flatpak run, the command-line tool to start a Flatpak application, accepted path strings, since flatpak run is assumed to be run by a trusted user. The problem lay in a D-Bus service sandboxed applications could use to create subsandboxes, and this service was built around, you guessed it, flatpak run. The issues in question, including this complete sandbox escape, have been addressed and fixed, but they highlight exactly the dangers that can come from opening files. This subsandboxing approach in Flatpak is built on assumptions from fifteen years ago, and times have changed since then. If you're a programmer who deals with opening files, you might want to take a look at your own code to see if similar issues exist.

24 Apr 2026 8:24pm GMT