fidzu : geek

Reuters reports "a major success in a new field of cancer treatment this week, as Moderna and Merck announced a personalized mRNA cancer vaccine "reduced the risk of recurrence and spread of melanoma in a late-stage trial". The vaccine was tested with Merck's widely used immunotherapy drug Keytruda: Thousands of patients who have undergone surgery to remove high-risk melanoma tumors could benefit as soon as next year if regulators approve the vaccine, Moderna President Stephen Hoge said in an interview. This is the first positive late-stage trial result for an mRNA cancer vaccine, which trains a patient's immune system to fight tumors by targeting specific mutations in those cells, and the first such study to show that adding a treatment to Keytruda worked better than that therapy alone... Interim results of the ongoing study, released on Wednesday, found the treatment, Intismeran, met both its primary target of reducing cancer recurrence and its secondary goal of preventing tumors from spreading to other parts of the body, compared with Keytruda alone. When the vaccine is injected into a patient, the patient's cells produce copies of mutations for the immune system to recognize and destroy... Merck said the companies are already in talks with regulators about the treatment. "Merck, Moderna and other companies are testing similar approaches against lung, breast and pancreatic cancers," the article points out. It adds that Karen Knudsen, CEO of the Parker Institute for Cancer Immunotherapy, "said the Moderna results could signal a new era for treating solid-tumor cancers." More from CNN: The trial result is "a monumental leap forward," validating mRNA technology as a cancer treatment, said Dr. Julie Gralow, chief medical officer of the American Society of Clinical Oncology... Roche and BioNTech, whose mRNA technology was used in the Pfizer COVID vaccines, are testing a similar treatment called autogene cevumeran in mid-stage studies in colon and pancreatic cancer patients who have undergone surgery. Results of the colon cancer trial are expected in 2027, with pancreatic trial results to follow in 2031. "We should be hearing results from multiple studies over the next few years and there's every reason to hope now, with this news, that many of them will be positive," said Dr. Robert Vonderheide, director of Penn Medicine's Abramson Cancer Center and president-elect of the American Association for Cancer Research.

Read more of this story at Slashdot.

22 Aug 2026 6:00pm GMT

47% of recent graduates say AI has already impacted hiring in their field, according to an April survey from ZipRecruiter. "But is AI really the problem, or is it more complicated?" asks NPR. "Here's what economists have to say." According to the Federal Reserve Bank of New York, the unemployment rate for recent graduates - which it defines as 22-to-27-year-olds with a new bachelor's degree or higher - was 5.7% as of June, more than the rate for all workers, which stands at 4.1%... Stanford University economist Erik Brynjolfsson says AI is impacting the labor market for entry-level roles. "AI is not the whole story, but it's part of the story and the evidence is building," he says. Using payroll data, Brynjolfsson and his co-authors found that since late 2022 - when large language models like ChatGPT started popping up - early-career workers ages 22 to 25 in AI-exposed roles, like software developers and marketing managers, have experienced a 16% relative employment decline. In comparison, employment rates for older workers in AI-exposed fields and for all workers in jobs that aren't easily automated - like home health aides, physical therapists and construction workers - remained stable or have grown over that same time period... [Though he also says often when companies pull back on hiring, they cut junior roles first.] Harvard University economist David Deming isn't convinced that AI is to blame for the challenging early-career job market. "If you look very carefully at the timing, it looks like the decline in junior hiring actually started a bit like six months before ChatGPT was released. And so what that tells me is it's something else," Deming says. "I think it's more like remote work." A recent analysis from the New York Fed found that companies are less likely to hire recent college grads into roles that can be done remotely. As remote jobs increased following the COVID-19 pandemic, so did unemployment among younger college grads, the New York Fed found. The analysis also found that AI didn't explain the rise in unemployment among younger workers and that remote work was more of a driving force... Employers hiring for remote jobs may be less likely to choose an entry-level candidate because it's harder to train them from afar... [And with remote positions, there's many more senior candidates to choose from.] And here's another thing to consider: University of Chicago economist Anders Humlum says if AI were replacing entry-level jobs, you'd expect to see companies that rely heavily on AI to hire fewer workers. But that's not what the data shows. Humlum points to a study done by the financial accounting firm Ramp and the workforce research company Revelio Labs. The study examined AI spending and employee head count across more than 21,000 U.S. firms, from early 2021 to early 2026. It found that at companies making the largest AI investments, entry-level head count grew by 12% over the two years following AI adoption.

Read more of this story at Slashdot.

22 Aug 2026 5:00pm GMT

Firefox 154 "brings a number of usability improvements," writes PC World: The free built-in VPN, introduced with Firefox 149, continues to offer a selection of virtual locations - temporarily extended to 28 countries until the end of August... The free VPN is currently available to Firefox users in the US, Canada, the UK, France, and Germany. In addition, the free VPN can now also be used in Firefox for Android (rolling out gradually) with iOS to follow soon. Firefox 154 also begins adding the privacy-focused search engine Startpage to its address-bar search options for desktop users in Germany, France, Austria, Switzerland, and the Netherlands (the home markets for the Netherlands-based search engine). And Startpage is also coming soon to Android and iOS. "When so much of the web experience is decided by a handful of very large companies, a search option that's private by design and European by origin isn't a small thing," explains a Mozilla blog post, with Ajit Varma, Head of Firefox, saying this now gives millions of people in Europe one-click access to "real results, zero profiling, AI-free." Queries aren't stored or linked to you, and there are no AI answers pushed above your search results. In fact, there's no AI at all. Based in the Netherlands, Startpage built its product around a simple idea: great search and personal privacy can go hand in hand... Firefox users were choosing Startpage long before today - to the tune of more than a billion searches a year, every one of them required some assembly: an extension, a manual setting, a workaround... Startpage ranks among the most-requested search engines in the Firefox community. When demand is this clear, our job is to remove the friction... Most browsers have already decided how you're going to search. Firefox hasn't. Pick your search engine, control what happens to your queries, decide who sees data about you, even turn AI on or off. It should always be your call. Not everyone wants the same thing from search, and a browser shouldn't pretend they do. "Firefox has always been the browser for people who want to make their own decisions about the web," said Startpage President Stewart Marlborough, "which makes it a natural home for private search." Nvidia's GeForce NOW cloud-gaming platform is also now officially supported on Firefox, expanding access across even more devices," according to a Nvidia blog post: Members can outfox big downloads and jump into high-performance PC gaming directly from the browser - no waiting on lengthy game installs or updates. The experience delivers GeForce RTX-powered performance at up to 1440p and 120 frames per second for GeForce NOW Ultimate members. Simply download the latest version of Firefox, head to play.geforcenow.com and start playing. The cloud handles the heavy lifting, so games are ready to play without taking up valuable storage space on the device. Firefox joins Chrome, Edge and Opera in supporting GeForce NOW on Windows browsers. Mozilla's own blog post even includes an animation of the Firefox mascot playing games: Gamers put real effort into making their rigs their own, and Firefox gets that. Users can choose themes, custom colors, and tab settings to customize their setup, instead of sitting there like just another window. We also know online gaming doesn't happen in just one window. It's social and sometimes spontaneous. With Firefox, you can have a Discord call running in Split View, a guide open in another tab, or Reddit pulled up between matches. Then go full screen when you're ready to play, no need to switch browsers to stream games. "In the security report for Firefox 154, Mozilla lists 58 resolved security vulnerabilities, 54 of which were discovered and reported by external security researchers," notes PC World. ("Mozilla classifies 17 of these vulnerabilities as high risk.") With Firefox 155 (scheduled for September 1), Mozilla is switching to a fortnightly release cycle for major versions, like Google Chrome and Microsoft Edge.

Read more of this story at Slashdot.

22 Aug 2026 4:00pm GMT

"We probably need another site that's capable of heavy and super heavy launch capability."

21 Aug 2026 11:32pm GMT

Thunderstorms make seismic waves that can be used to find sub-surface features.

21 Aug 2026 8:26pm GMT

Renters say hidden Zillow listings make it harder to afford living in New York City.

21 Aug 2026 8:10pm GMT

When I wrote about using Windows 11 for a month as part of the ongoing OSNews fundraiser (keep donating to get me to do the same for macOS!), one of the things I mentioned was that "the modern desktop context menu has its own classic Win32 context menu". This is, in fact, a long-standing complaint I've repeatedly used as the perfect example of just how chaotic and low-quality Windows has become. Thankfully, and naturally I fully attribute this to my repeated complaints (*), Microsoft has been working on a brand new, faster, configurable context menu, and Neowin actually reviewed it. If you ask me, this revamped context menu addresses just about the biggest problem users had with the one in Windows 11, and that is the need to click through more buttons than necessary to do simple things like renaming a file or opening its properties. That problem is now basically gone. I have no issues with the new design. It looks modern, it feels more consistent with the rest of Windows, and even though all the new sections can still make it look a little busy, you now have the option to make it as simple or as button-packed as you want. That should cover most use cases and preferences well. I'd even say that when the new context menu becomes available to everyone, my guide on how to bring back the classic context menu might become obsolete. ↫ Ivan Jenic at Neowin The biggest reason I'm linking to this is not because I care about whatever monster of a context menu Windows users are having to deal with. No, I'm only linking to this because I never in my life imagined I'd be linking to a review of a context menu. I mean, at least it's not the chess application icon. That would be embarrassing. I get a perverse sense of joy out of this.

19 Aug 2026 9:58pm GMT

A great and concise history of the run-up to MS-DOS 2.0. Yet, there was a nagging feeling that a single-tasking CP/M clone was inadequate for the new generation of personal computers. Digital Research released multi-user, multitasking MP/M-86 in September 1981 and announced the single‑user multitasking Concurrent CP/M in early 1982. In response, Microsoft came up with a plan for tiered approach to its operating systems: single-user/single-tasking MS-DOS at the bottom; multi-user/multitasking XENIX at the top; and in the middle, something called XEDOS: a single-user version of XENIX. This "pyramid of upward-compatible operating systems" was announced in a Byte Magazine editorial in January 1982. ↫ Nemanja Trifunovic I've always found this tiered approach fascinating, and the world surely would've looked quite different had Microsoft been able to make it work. I doubt Windows NT would ever have existed, and most of the world would probably be running a XENIX-based Windows today (all else being equal, which is of course unlikely and silly). Regardless, MS-DOS 2.0 contained a few UNIX-like utilities to deal with its brand new support for directory trees and other new features, and even had a /dev directory.

18 Aug 2026 9:59am GMT

If you thought pervert glasses weren't bad enough, Apple is taking it up a notch by adding cameras to its AirPods. Apple is working on camera-equipped AirPods that appear to be nearly ready to launch, based on a video MacRumors found in the macOS Tahoe 26.7 release candidate. In a short demo, a man holds a book up so the camera in the AirPods can see the title. "With Visual Intelligence, your world becomes savable. See something you like? Just ask me to save it for later," says the voiceover text. ↫ Juli Clover at MacRumors AirPods are tiny. I've seen people use them at the gym. I've seen them on playgrounds. I've seen them around swimming pools. People use them at the beach. They're used at schools. In locker rooms. Tiny cameras in tiny AirPods that can photograph anything in front of the user are a pervert's wet dream. Abusers are going to love this. Why wear bulky glasses anyone can see and try to demand you take off, when you can wear tiny AirPods that have already been fully normalised in society? Was there not a single woman or parent on the team that made this? All over the United States, people are destroying Flock surveillance cameras. More and more communities are rising up and demanding these things removed from their streets and neighbourhoods. The awareness of just how pervasive mass government surveillance has become is growing, and Silicon Valley's complicity is not exactly a secret. And in this climate of rapidly growing concern and anger, Apple is going to add tiny cameras to its tiny AirPods. Was there not a single person of colour or protester on the team that made this? How detached from reality do you have to be to greenlight something like this? Does anyone - regardless of skin colour, gender, or political leaning - want even more cameras around them?

18 Aug 2026 9:41am GMT

Over the last few weeks, we have been doing research on the integration of our official distribution packages when installed on a target system. In this context we have been looking at the current uses of alpm-install-scriptlet(5) files and alpm-hooks(5) in around 120 package source repositories (alpm-source-repo(7)) to better understand the underlying functionality and use-cases these two integrations offer and target. In this article we are going to look at how these two systems work, how Arch Linux is currently using them and attempt to provide suggestions for when to use which. Learning about alpm-hooks(5) and alpm-install-scriptlet(5) files …

09 Aug 2026 12:00am GMT

This is just a short note on my blog that I have resigned from Arch Linux a package maintainer, developer and security team. I've spent around 10 years as an AUR maintainer, security team, Package Maintainer and then Developer. I implemented support for debug packages, did the initial POC work that would become the git migration and even somehow managed to pull of an online conference during The Plague with the help of others.

01 Aug 2026 12:00am GMT

Good morning from JetBrains Berlin office!

01 Jun 2026 12:00am GMT