fidzu : geek

An anonymous reader quotes a report from The Guardian: Miniature human organs and other tissues are to be grown from NHS patients' cells in a drive to improve medicine testing and reduce the number of animals used in drug development. Scientists will use the clumps of tissue to learn how diseases vary between patients, helping them identify which treatments are best for different people based on the particular pathology underlying their condition. The move marks a shift away from the traditional use of animals as models for human disease, towards what researchers believe will be more accurate and reliable tests based directly on human tissues. Researchers have been growing tiny clumps of human organs, known as organoids, for more than a decade. Tests show that pieces smaller than a millimeter can mirror key features of full-scale organs and tissues, including how they falter with disease and respond to drugs. Armed with organoids grown from diseased human tissues, scientists can investigate whether new drug candidates reverse pathological changes in all or a subset of patients, and quickly identify ineffective drugs early in the process. Historically, more than 90% of drugs that clear animal testing go on to fail in human trials, raising questions about the value of the tests. US and European medicines regulators now encourage other approaches if available. "It's going to have a major impact on the numbers of animals used and the way we develop new drugs in the future," said Matthias Zilbauer, a clinical professor of paediatric gastroenterology at the Cambridge Stem Cell Institute. "We're not saying there won't be any animal use in the near or foreseeable future, because there are still certain issues that cannot be tested in these new models, but the reduction is very real." "A lot of human diseases either do not occur in animals or occur in a different way because they're not human," added Zilbauer. "We want tests and models that can tell us which treatments work, and in what patients, and a mouse cannot tell us that."

Read more of this story at Slashdot.

14 Aug 2026 3:30am GMT

Microsoft has been steadily scaling back its China presence, closing at least 15 branch offices and joint ventures over the past five years as Beijing favors domestic software. U.S. export controls also make it harder to grow its cloud and AI businesses, leaving the market with relatively little economic upside. Reuters reports: Microsoft took a major hit from the erosion of trust between Washington and Beijing, the five people said. China has since 2017 pushed the use of domestic software, which Beijing sees as more secure and whose quality is increasingly competitive with Windows and Office. U.S. restrictions, including export controls on advanced technology, have meanwhile hindered efforts to scale Microsoft's lucrative AI and cloud businesses in China. [...] Microsoft ultimately decided to remain because it had carved out a profitable business servicing Chinese companies like TikTok owner ByteDance, which need Western technology to manage overseas operations, according to three people familiar with the matter. The company also believed that it needed a presence to maintain access to China's world-class engineering talent, two of them said. Microsoft had also cultivated a relationship with the government that is among the deepest of any tech company, its former China head Alain Crozier told Reuters. "Because of the geopolitics ... some days it's a little bit harder, but we never had a crisis," he said. A Microsoft spokesperson did not address questions about the firm's deliberations on its China business but said it operates in a regulatory "environment that applies to every international supplier" and that it remains committed to the Chinese market. The state of Microsoft's China business reflects market competition, regulatory demands and technological trends, the company said.

Read more of this story at Slashdot.

13 Aug 2026 11:00pm GMT

Study finds wait times for cancer surgeries hit 10-year high.

13 Aug 2026 10:17pm GMT

Google has released Gemini 3.7 Flash just three weeks after 3.6 Flash, focusing on better coding, agentic workflows, and enterprise automation while temporarily cutting API prices in half through the end of 2026. VentureBeat reports: For enterprise developers, the more consequential story may be the combination of those intelligence gains with lower inference costs: through the end of 2026, Gemini 3.7 Flash costs $0.75 per million input tokens and $3.75 per million output tokens. Starting Jan. 1, 2027, pricing rises to $1.50 per million input tokens and $7.50 per million output tokens. That means the current discount is temporary, but it gives teams deploying high-volume coding and business agents several months to evaluate whether Google's claimed reductions in retries and manual oversight translate into lower total operating costs. The launch also underscores Google's rapid iteration on its Flash line while its next flagship Pro model remains absent. [...] Google describes Gemini 3.7 Flash as its "most intelligent workhorse model yet for coding and agents." The company says the model is better at adapting when it encounters roadblocks, clarifying intent when necessary and following instructions with greater fidelity. [...] Google's benchmarks show a large generational improvement in several software engineering tests. [...] Google's own results do not show 3.7 Flash universally displacing higher-priced competitors. They instead suggest a model that has become substantially more competitive in coding and agent workloads while occupying a lower price tier.

Read more of this story at Slashdot.

13 Aug 2026 10:00pm GMT

Trump memo is first time gov't has authorized private sector to perform cyberattacks.

13 Aug 2026 7:38pm GMT

Will it be the VSS... Horizon, Explorer, Ascend or Apeiron?

13 Aug 2026 7:12pm GMT

Another month started almost two weeks ago, so we've got a new monthly report from Redox, the general purpose operating system written in Rust. The month of July - it seems the report was published with a bit of a delay, regardless of what the date on their site says - brought improvements to the installer, with new options commonly found in most installers, such as a choice of installation method, network-based installation, and more. The Google Summer of Code work on the new CPU scheduler has also been merged, including a number of related performance enhancements. There's improvements to the ARM port, Amlogic Meson UART ARM64 support, and uutils grep and sed have been successfully built on Redox, replacing their their GNU counterparts in the os-test test suite. In addition, a whole slew of demos were ported as well, from Ratatui demos to various Iced demos covering things like reading QR codes and processing Markdown. Of course, this is all topped off with the usual long list of lower-level, smaller changes and improvements to the kernel, drivers, Relibc, and more.

12 Aug 2026 11:15pm GMT

The OSNews Fundraiser, to celebrate the fact I posted 20000 stories in 21 years, is still underway. The first major incentive was reached, and I, a long-time Linux user, published my experiences using Windows 11 for a month. It wasn't a success. Keep donating if you want to find out what a Linux user thinks of the current state of macOS! ➡️ Donate through Ko-Fi ➡️ Donate through SEPA transfer* ➡️ Buy merch from our store ➡️ Why a fundraiser? €5000 incentive: Make me use Windows 11 for a month (the results were not great)> €10000: Video tour of my office and my computers/devices collection <€15000: Buy a Mac and use macOS for a month (and review it)€20000: I get an OSNews tattoo *Name: Thom Holwerda - IBAN: SE08 8000 0820 1684 4657 8414 - BIC: SWEDSESS Why support OSNews? I want to make sure I can run OSNews for another two decades and another 20000 posts, and I need your help to do so. Since my wife, who has a tough, underpaid job in elderly care, is largely unable to work due to health reasons caused by that very same job, my income has become a lot more crucial for our kids, my wife, and myself. With OSNews readers being more skeptical of subscription-like things like our Patreon than most people, it's exactly these one-time donations that make up the bulk of your support. Thank you.

12 Aug 2026 6:40pm GMT

Raymond Chen explains what, exactly, the file winstart.bat in Windows 95 is used for. In Windows 95, you could create a winstart.bat file in your Windows directory. During startup, the virtual machine manager initializes and creates the so-called "System virtual machine" (the "System VM"), which is the virtual machine that all Windows programs run in. But before running the user-mode kernel in that virtual machine, the virtual machine manager runs the winstart.bat batch file if it exists. ↫ Raymond Chen Chen needs to use several diagrams to really explain what the batch file is used for, but as a very crude summary, it allows you to load TSRs that only apply to Windows programs, while not affecting any additional DOS command prompts you may load later after Windows is already running. While many think it's a Windows 95 feature, it was already present in Windows 3.x. A unique feature that I doubt many people made active use of.

12 Aug 2026 6:24pm GMT

Over the last few weeks, we have been doing research on the integration of our official distribution packages when installed on a target system. In this context we have been looking at the current uses of alpm-install-scriptlet(5) files and alpm-hooks(5) in around 120 package source repositories (alpm-source-repo(7)) to better understand the underlying functionality and use-cases these two integrations offer and target. In this article we are going to look at how these two systems work, how Arch Linux is currently using them and attempt to provide suggestions for when to use which. Learning about alpm-hooks(5) and alpm-install-scriptlet(5) files …

09 Aug 2026 12:00am GMT

This is just a short note on my blog that I have resigned from Arch Linux a package maintainer, developer and security team. I've spent around 10 years as an AUR maintainer, security team, Package Maintainer and then Developer. I implemented support for debug packages, did the initial POC work that would become the git migration and even somehow managed to pull of an online conference during The Plague with the help of others.

01 Aug 2026 12:00am GMT

Good morning from JetBrains Berlin office!

01 Jun 2026 12:00am GMT