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22 Oct 2026 3:47am GMT

An anonymous reader quotes a report from The New York Times: For the first time, scientists say they have used viruses designed by artificial intelligence to treat a human patient. Researchers announced on Tuesday that they had administered the virus, known as a phage, to a patient suffering from a deadly bacterial infection. Phages attack bacteria, and the hope is that this one will kill the microbes causing the infection. Radical Numerics, the start-up that created the viruses, posted a technical report about them on its website. But the company declined to provide information about the patient or the doctors running the trial, citing confidentiality requirements. [...] In 2025, researchers at the Arc Institute in Palo Alto, Calif., created an A.I. model called Evo 2, which they trained on millions of DNA sequences, including phage genes. They prompted Evo 2 to make new genomes similar to those in a group of phage species. The A.I. generated 700,000 virus genomes. The team synthesized DNA molecules from 285 genomes and inserted them into bacteria. The researchers found that 16 of the genomes gave rise to viable viruses. Three members of the Evo team, including Dr. Nguyen, left to found Radical Numerics. In June, the company unveiled a new A.I. model, called Omnii, based on some of the same principles as Evo. Omnii can be trained not just on DNA but also on other aspects of biology, such as the structures of proteins and molecules that keep genes turned on or off. The company is now using Omnii to tackle a range of challenges, including designing cancer vaccines and recognizing the risk that a virus may cause a pandemic. Among these efforts is the first trial of A.I.-designed phage therapy. The researchers created variations of a phage called T7. The virus, which only infects E. coli, looks like a microscopic Apollo lunar lander: a ball-shaped protein shell that holds its DNA atop six leglike protrusions. To infect a bacterium, T7 lands on its surface, using its legs to anchor in place. It then injects its DNA into the cell. Omnii generated new viral genes altering the shapes of T7's legs, according to Dr. Nguyen and his colleagues. While some of the new legs were significantly different from natural ones, Omnii's phages could still infect bacteria. Once the researchers were confident their strategy had worked, they partnered with doctors treating a patient with a stubborn E. coli infection. The bacteria had resisted not just antibiotics but all the available phages. The researchers said they had trained Omnii with information about the resistant strain and told it to design T7 phages with legs that could grab onto the bacteria. Once the A.I. generated genomes for new viruses, the scientists said they produced the corresponding DNA molecules and inserted them in bacteria. The bacteria became infected and produced T7 phages that could successfully infect, and kill, other microbes. After running tests to make sure the phages were safe, Radical Numerics presented them to the doctors. The F.D.A. authorized a trial. While the trial was authorized by the FDA, it's worth noting that the research has not yet been peer-reviewed in a scientific journal and there's no guarantee the AI-designed phages will work. However, if it does prove successful, it could help speed phage therapy by cutting down the time it takes to create a new virus tailored to each patient's infection. "We think we can get it done in days," said Dr. Eric Nguyen, the chief executive officer of Radical Numerics.

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22 Oct 2026 3:30am GMT

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22 Oct 2026 2:30am GMT

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22 Oct 2026 2:18am GMT

eBay plans to cut about 1,000 jobs, or 9% of its workforce, as CEO Jamie Iannone moves to redirect resources toward the company's fastest-growing businesses. Reuters reports: The company had 12,300 employees at the end of last year. It also let go about 6% of its workforce, or 800 employees, in February as part of efforts to streamline operations. EBay has set itself apart from rivals by pushing into authenticated luxury goods, collectibles and refurbished products, which draw enthusiasts willing to pay more for valuable items. That has helped its shares rise nearly 40% this year, outperforming the benchmark S&P 500's around 12% gain. "Our strategy is working," Iannone said in the memo, adding that "continuing to capture the significant opportunity ahead requires us to make thoughtful choices about where we focus and invest." He said affected staff would be informed in the coming days.

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21 Oct 2026 11:00pm GMT

DietPi 10.8 introduces a WireGuard management tool, named software IDs, HAProxy security improvements, and networking fixes.

21 Oct 2026 10:47pm GMT

KeePassXC 2.8 arrives with Qt 6, Wayland Auto-Type support, Linux Quick Unlock, remote database syncing, and important security fixes.

21 Oct 2026 10:28pm GMT

Ex-FCC chairs say Brendan Carr aims to scare broadcasters into self-censorship.

21 Oct 2026 10:17pm GMT

Time-based a la carte charges come on top of the purchase price for the games themselves.

21 Oct 2026 10:06pm GMT

AMD has published Linux kernel patches for an official Ryzen overclocking driver that allows users to adjust CPU power and current limits through a firmware interface exposed via sysfs. Phoronix reports: AMD engineer Shyam Sundar S K posted the patches for the AMD Overclocking "AOD" WMI driver as an interface to the platform firmware for managing overclocking and power/current limits of modern Ryzen CPUs. The driver in its initial form allows setting via sysfs a number of CPU tunables including the Package Power Tracking (PPT), Thermal Design Current (TDC), and Electrical Design Current (EDC) limits along with reading their supported range. SMT toggling can also be done via the interface as an alternative to the likes of Linux's "nosmt" option in disabling SMT at the platform level rather than kernel disabling. The current memory clocks can also be read via this AOD driver. The power tunables aren't applied in real-time but go into effect at next reboot. The firmware does support many more commands compared to the few initially wired up and hopefully in time more of these controls will be enabled with this driver.

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21 Oct 2026 10:00pm GMT

Survey of 2,018 IT heads at big firms points to a lack of leverage.

21 Oct 2026 9:48pm GMT

LibreOffice records 9.4 million downloads in eight weeks, with 2026 download figures already exceeding the entire 2025 total.

21 Oct 2026 6:12pm GMT